6,214 thoughts on “Bryan Shaw (Oct. 5)

  1. My first impression of the article was that the introduction was full of lots and lots of ideas. It was really interesting to see how the researchers tackled creating totally new hypotheses based on the known facts (specifically the correlation between non-covalent bonding interactions and specific categories of diseases). Though the studies that are geared more towards modification or extensions of previous ones are themselves invaluable, I appreciated the opportunity to gain more insight on how new studies and new hypotheses are built. I also liked that the article clearly outlined what the next steps would need to be to further this study. This sort of hardened the argument of this research’s potential.

  2. From reading this article, I did get what their end goal was. It is quite interesting that though we know that proteins could interact as such, there is still more that could be done by increasing the net charge of the protein itself. There were some terms which I could not understand thus making it quite difficult to read the whole paper. However, I look forward to the talk so that I could learn more on the details of the proteins and such modifications.

  3. This article is actually really interesting and the research is actually pretty important because my mom was actually diagnosed with ALS a little over a year ago. It’s a little disappointing that the data collected did show that an acetylating agent like aspirin could not act as a charge boosting drug while treating ALS, but as stated in the conclusion the Shaw group is hopeful in finding a new drug in place of aspirin. With the large influx of donation and funding there is plenty of resources readily available for this lab and lots of other labs throughout the world to find a cure for this disease.

  4. What I found to be the most interesting portion of this article was in all the areas that they can now delve into with this study being done. This paper took an idea which ultimately did not achieve the intended results but did allow them to gain more knowledge such as the nonspecific acetylation which they observed but with an idea to acetylate at a different surface on the protein to give a more promising result. This research group seems to have a good grasp on where they should go next to examine different strategies to inhibit aggregation and since this was published fairly recently I am curious if they have started on these projects – specifically the structure and other properties of the oligomers.

  5. One of the amazing things I learnt from this article is that even the most studied drugs (aspirin in this case) can be involved in vivo mechanism that people never thought about, and lead us to brand new fields. This article is great because it showed a new aspect of drug targeting, though not yet mature, that can be very promising in the future.

  6. This article was really interesting in terms of its approach. I could see and understand author’s notion of carrying out this research from the introduction. Its great to see how researchers are putting so much effort in generating new pathways to retard/cure ALS, successful or unsuccessful that’s a different story. I highly appreciate how the author highlights future of this research at the end and clearly states what alternate strategies can be adopted, and what all didn’t work in his case. This field of research seems to have a great potential.

  7. What intrigued me the most about this paper was the novel approach the researchers utilized in tackling a critical issue. Although they were unsuccessful in their endeavors, I was able to appreciate the method by which they pursued their interests. I hadn’t really thought that a protein’s net charge could be something that could be targeted for a drug response. I wish to learn more about the potential treatment through this method so I am looking forward to the talk.

  8. Before reading this article, I never considered all the different uses for aspirin. It was interesting to see how this compound could be used for treating much more than just headaches. Like some others have already stated, I also enjoyed how this paper explained the thought process of the experiment. It is neat to read about what inspired this type of research and how the researchers formed many of their hypotheses. Unfortunately, this research did not produce the results they were hoping for, that aspirin could be used as a charge boosting drug. However, the conclusions made from the research will be extremely useful for future work and proved that this research was not a waste of time.

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